Leonardo da Vinci (1452-1519) was born in Anchiano, Tuscany (now Italy), close to the town of Vinci that provided the surname we associate with him today. In his own time he was known just as Leonardo or as “Il Florentine,” since he lived near Florence—and was famed as an artist, inventor and thinker.

Da Vinci’s parents weren’t married, and his mother, Caterina, a peasant, wed another man while da Vinci was very young and began a new family. Beginning around age 5, he lived on the estate in Vinci that belonged to the family of his father, Ser Peiro, an attorney and notary. Da Vinci’s uncle, who had a particular appreciation for nature that da Vinci grew to share, also helped raise him.

The first is da Vinci’s “The Last Supper,” painted during his time in Milan, from about 1495 to 1498. A tempera and oil mural on plaster, “The Last Supper” was created for the refectory of the city’s Monastery of Santa Maria delle Grazie. Also known as “The Cenacle,” this work measures about 15 by 29 feet and is the artist’s only surviving fresco. It depicts the Passover dinner during which Jesus Christ addresses the Apostles and says, “One of you shall betray me.” One of the painting’s stellar features is each Apostle’s distinct emotive expression and body language. Its composition, in which Jesus is centered among yet isolated from the Apostles, has influenced generations of painters.

When Milan was invaded by the French in 1499 and the Sforza family fled, da Vinci escaped as well, possibly first to Venice and then to Florence. There, he painted a series of portraits that included “La Gioconda,” a 21-by-31-inch work that’s best known today as “Mona Lisa.” Painted between approximately 1503 and 1506, the woman depicted—especially because of her mysterious slight smile—has been the subject of speculation for centuries. In the past she was often thought to be Mona Lisa Gherardini, a courtesan, but current scholarship indicates that she was Lisa del Giocondo, wife of Florentine merchant Francisco del Giocondo. Today, the portrait—the only da Vinci portrait from this period that survives—is housed at the Louvre Museum in Paris, France, where it attracts millions of visitors each year.